St Peter’s Trust Research Projects
GRANTS AWARDED IN 2020
To begin in the 2020/21 academic year
2020 was a bumper year for the trust because £250,000 was available and there were many excellent applications. We were able to fund almost all of them.
£100,000 had been allocated for a PhD studentship. There were three applications and the award was made to a project entitled:
Exploring the mechanisms of AKI using novel in vitro culture system …
Under the direction of Dr Klootwijk and Professor Salama for £90,612.
Acute Kidney Injury (AKI) occurs with several serious illnesses, especially infections. The mechanism of causation is not fully understood. With early detection it is treatable, but delay is often fatal. It is a national priority to research this field.
The remaining money was allocated to eight projects and one piece of equipment. There was a good spectrum of laboratory and clinical projects in Urology and Nephrology:
1. Tyrosine kinase profiling to predict disease remission and treatments needs in Lupus nephritis.
Vajgel/Salama – £25,000
2. Pilot study to investigate feasibility & acceptability of sestamibi SPEC/CT for renal mass characterisation.
Tran/Wagner – £24,828
3. Mechanisms of paracellular phosphate absorption and its regulation.
Marks – £15,198
1. Asowata EO, Olusanya O, Abaakil K, Chichger H, Srai SKS, Unwin RJ, et al. Diet-induced iron deficiency in rats impacts small intestinal calcium and phosphate absorption. Acta Physiol (Oxf). 2021:e13650.
2. Hernando N, Pastor-Arroyo EM, Marks J, Schnitzbauer U, Knopfel T, Burki M, et al. 1,25(OH)2 vitamin D3 stimulates active phosphate transport but not paracellular phosphate absorption in mouse intestine. J Physiol. 2021;599(4):1131-50.
4. Digital redesign of electronic-Patient reported outcome measures (e-PROM) data collection for Uro-oncology clinical research at UCL and UCLH: pilot.
Dinneen/Shaw/Kelly – £11,100
5. Development of a point of care device to monitor kidney transplant rejection.
Motallebzadeh – £11,713
6. Variability in expression of Methylmalonyll-CoA mutase as a risk for dehydration related acute kidney injury.
Oomatia/Caplin – £13,550
7. Antenatal gene therapy to correct bladder dysfunction in posterior urethral valves.
Winyard/Long – £31,250
8. Anti-fibrotic therapy for bladder dysfunction in posterior urethral valves.
Johal/Fry/Winyard – £24,375
1. Sample Processing Devices for rapid optical clearing and immunostaining of intact 3D tissue samples.
Walsh/Siew/Salama – £24,945
GRANTS AWARDED IN 2019
1. Renal Cancer Tumouroids: New generation 3D in vitro models created from individual patients for testing drug responses.
Loizidou/Tran/ Yaghini – £84,154
2. A Novel therapeutic target in acute kidney injury.
Haschler/Norman/Alan Salama – £11,000
GRANTS AWARDED IN 2018
1. Testing a complement inhibitor.
Marks/Gale – £24,645.47
2. Influence of the gut and urinary microbiota on outcomes after renal transplantation.
Motallebzadeh – £24,979
3. Domiciliary REcovery After Medicalisation Pathway (DREAM Path).
Khetrapal – £24,500
4. Genetic analysis using high performance computing in chronic kidney disease.
Stanescu – £24,817.26
Purchase of a next generation Azure c600 chemiluminescent, UV, RGB and laser NIR imaging system for the Centre for Nephrology. This replaces a piece of equipment that is no longer fit for service. It will be shared by several groups in the laboratory – £24,996.79.