Researchers identified that an amino acid peptide sequence could potentially block signals from the immune cells that contribute to pulmonary fibrosis, the scarring process seen in systemic sclerosis.
Professor Richard Stratton, consultant rheumatologist, said: “In our laboratory research, we found evidence that this amino acid sequence can effectively interfere with the pro-fibrotic signals emitted by the scleroderma-affected cells while leaving the healthy immune cell function intact.
“Our initial research shows us that in controlled research conditions, it’s possible to interfere with the process that causes lung fibrosis. Now, we want to investigate these findings further to see if we can translate that research into new treatments in the form of medicines.
“If successful, this offers hope for improved outcomes and quality of life for our patients affected by inflammatory fibrosis.”
The Royal Free Charity funded the two-year research project jointly with the medical research charity Rosetrees Trust, with each organisation contributing £10,000.
Thanks to the success of the initial trial, Prof Stratton’s team has secured a funding injection of £778k from UCL to fund the further research needed to test the new treatment in clinical trials.